What is the CAS number for RAD140?

The CAS number of RAD140 is 1182367-47-0.

What is RAD140 (1182367-47-0) used for?

RAD140 (also known as Testolone) is an oral nonsteroidal selective androgen receptor modulator (SARM) that cannot be converted to estrogen by aromatase. It has been demonstrated that RAD140 has high AR affinity and target selectivity, showing marked tissue-selective AR agonist activity comparable to natural androgens in breast cancer cells, while lacking agonist activity in prostate cancer cells.We have recently reported anti-tumor activity of RAD140 in multiple in vivo and in vitro models of AR/ER+ breast cancer as a single agent and in combination with inhibitors of CDK4/6 and mTOR.Pharmacodynamic investigation indicates RAD140 acted as an AR agonist in breast cancer cells while suppressing ER signaling and reduced ESR1 mRNA expression.RAD140 exhibited anti-tumor activity in patient-derived xenograft (PDX) models of AR/ER+ breast cancer, as single agent and in combination with inhibitors of CDK4/6 or mTORRAD140 inhibited ER signaling and ESR1 mRNA level in the HBCx-22 PDX model.

What is the CAS number for RAD140?

The CAS number of RAD140 is 1182367-47-0.

What is RAD140 (1182367-47-0) used for?

RAD140 (also known as Testolone) is an oral nonsteroidal selective androgen receptor modulator (SARM) that cannot be converted to estrogen by aromatase. It has been demonstrated that RAD140 has high AR affinity and target selectivity, showing marked tissue-selective AR agonist activity comparable to natural androgens in breast cancer cells, while lacking agonist activity in prostate cancer cells.We have recently reported anti-tumor activity of RAD140 in multiple in vivo and in vitro models of AR/ER+ breast cancer as a single agent and in combination with inhibitors of CDK4/6 and mTOR.Pharmacodynamic investigation indicates RAD140 acted as an AR agonist in breast cancer cells while suppressing ER signaling and reduced ESR1 mRNA expression.RAD140 exhibited anti-tumor activity in patient-derived xenograft (PDX) models of AR/ER+ breast cancer, as single agent and in combination with inhibitors of CDK4/6 or mTORRAD140 inhibited ER signaling and ESR1 mRNA level in the HBCx-22 PDX model.

Factory supply RAD140 1182367-47-0 with sufficient production capacity

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RAD140

Product Name
CasNo
MF
MW
Content
Appearance
Packing
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RAD140
1182367-47-0
C20H16ClN5O2
393.832
A crystalline solid

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Factory supply RAD140 1182367-47-0 with sufficient production capacity We supply high quality RAD140 (CAS 1182367-47-0), in stock, factory directly supply to clients, lower prices, more competitiveness.

What is the RAD140 ?

RAD140 is A crystalline solid, while it's Molecular Formula is C20H16ClN5O2. RAD140 is a potent, orally bio-available, and non-steroidal selective androgen receptor modulator (SARM) for the treatment of conditions such as muscle wasting and breast cancer.

How to get the best price on RAD140?

Revo Chemical Co., Ltd is a quality supplier and manufacturer of RAD140 . You can buy high quality, low price RAD140 1182367-47-0 here. Contact us.

Address:RM 03, 24/F, HO KING COMM CTR, 2-16 FAYUEN ST, MONG KOK, HONG KONGE-mail：sales@revochemical.com

Tel：0086-176 0651 7746

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RAD140

What is the RAD140 ?

How to get the best price on RAD140?