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β-ESTRADIOL


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  • β-ESTRADIOL
  • 50-28-2
  • C<sub>18</sub>H<sub>24</sub>O<sub>2</sub>
  • 272.387
  • white crystalline powder
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1.What is the β-ESTRADIOL ?

β-Estradiol is an endogenous estrogenic hormone receptor (ER) agonist (Ki values are 0.12 and 0.13 nM for ERα and ERβ respectively). Also high affinity ligand at membrane estrogen GPR30 receptors. β-Estradiol is an activator of PI 3-kinase.Estradiol (17β-estradiol, β-Estradiol, E2, 17β-Oestradiol) is a human sex hormone and steroid, and the primary female sex hormone. Estradiol upregulates IL-6 expression through the estrogen receptor β (ERβ) pathway.

Estradiol USP (Estrace) is used to treat Breast cancer; prostatic carcinoma.

2.What is the CAS number for β-ESTRADIOL ?

The CAS number of β-ESTRADIOL is 50-28-2.

More information of β-ESTRADIOL 50-28-2 are:

CAS Number

50-28-2

Density

1.17 g/cm3

Melting Point

178-179 °C(lit.)

Boiling Point

445.917 °C at 760 mmHg

Flash Point

209.634 °C

Vapor Pressure

9.82E-09mmHg at 25°C

Refractive Index

80.4 ° (C=1, Dioxane)

HS CODE

29372390

PSA

40.46000

LogP

3.60920

Pka

pKa 10.71±0.02(H2O(0.1% p-dioxane) t=25±0.1 I=0.03(KCl))(Approximate)

3.What is the molecular formula of β-ESTRADIOL ?

The chemical formula of β-ESTRADIOL is C18H24O2 which containing 18 Carbon atoms,24 Hydrogen atoms and 2 Oxygen atoms,and the molecular weight, and the molecular weight of β-ESTRADIOL is 272.387

4.What is β-ESTRADIOL(50-28-2)used for?

β-Estradiol is an endogenous estrogenic hormone receptor (ER) agonist (Ki values are 0.12 and 0.13 nM for ERα and ERβ respectively). Also high affinity ligand at membrane estrogen GPR30 receptors. β-Estradiol is an activator of PI 3-kinase.Estradiol (17β-estradiol, β-Estradiol, E2, 17β-Oestradiol) is a human sex hormone and steroid, and the primary female sex hormone. Estradiol upregulates IL-6 expression through the estrogen receptor β (ERβ) pathway.

InChI:InChI=1/C18H24O2/c1-18-9-8-14-13-5-3-12(19)10-11(13)2-4-15(14)16(18)6-7-17(18)20/h3,5,10,14-17,19-20H,2,4,6-9H2,1H3/t14-,15-,16+,17+,18+/m0/s1

Relevant articles related to β-ESTRADIOL:

Article

Source

ANDROGEN METABOLISM IN MALE AND FEMALE BREAST TISSUE

Perel, E.,Davis, S.,Killinger, D. W.

, p. 345 - 352 (1981)

-

Whitman,Wintersteiner,Schwenk

, p. 789,794 (1937)

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