- Product Name
- CasNo
- MF
- MW
- Content
- Appearance
- Packing
- Apply
- Estradiol
- 57-91-0
- C<sub>18</sub>H<sub>24</sub>O<sub>2</sub>
- 272.387
- White solid
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Estradiol (known as α-Estradiol or 17 α-Estradiol) is a biologically active estrogen in human breast cancer cells in tissue culture. 17-Εstradiol and its selective receptor, ER-X, are not part of a classical hormone/receptor endocrine system but of a system with important autocrine/paracrine functions in the developing and adult brain. 17-Estradiol may have enormous implications for hormone replacement strategies at the menopause and in the treatment of such neurodegenerative disorders as Alzheimer’s disease and ischemic stroke.
Estrone
estradiol
α-estradiol
| Conditions | Yield |
|---|---|
|
With
ethanol; nickel;
at 120 ℃;
under 14710.2 Torr;
Hydrogenation;
|
|
|
With
potassium hydroxide; aluminum nickel;
at 80 - 90 ℃;
|
|
|
With
aluminum isopropoxide; isopropyl alcohol;
|
|
|
With
<(+)-(2R,3R)-O-isopropylidene-2,3-dihydroxy-1,4-bis(diphenylphosphino)butane (diop)>Rh(solvent)Cl; diphenylsilane;
In
xylene;
at 22 ℃;
Product distribution;
|
|
|
With
diphenylsilane;
(-)DIOP-Rh;
In
xylene;
at 75 ℃;
for 2h;
Mechanism;
Product distribution;
also at 5 degC, other time , also (+)DIOP-Rh, other solvent;
|
|
|
Estrone;
In
2-methyltetrahydrofuran;
Inert atmosphere;
Reflux;
With
aluminum tri-sec-butoxide;
In
2-methyltetrahydrofuran;
for 18h;
Inert atmosphere;
Reflux;
|
23.5 g |
|
With
isopropyl alcohol;
at 80 ℃;
for 24h;
Reagent/catalyst;
Time;
chemoselective reaction;
Catalytic behavior;
|
24 % de |
|
With
Zr-containing metal-organic framework-808;
In
iso-butanol;
at 119.84 ℃;
for 8h;
Solvent;
Reagent/catalyst;
diastereoselective reaction;
|
74 % de |
|
With
aluminum isopropoxide;
In
iso-butanol;
at 119.84 ℃;
for 24h;
Reagent/catalyst;
|
32 % de |
estrone p-toluenesulfonylhydrazone
estradiol
α-estradiol
| Conditions | Yield |
|---|---|
|
With
sodium tetrahydroborate;
In
water; isopropyl alcohol;
for 16h;
Yield given. Yields of byproduct given. Title compound not separated from byproducts;
Ambient temperature;
|
The CAS number of Estradiol is 57-91-0.
More information of Estradiol 57-91-0 are:
|
CAS Number |
57-91-0 |
|
Density |
1.17 g/cm3 |
|
Melting Point |
176-180 °C(lit.) |
|
Boiling Point |
445.9 °C at 760 mmHg |
|
Flash Point |
209.6 °C |
|
Vapor Pressure |
9.82E-09mmHg at 25°C |
|
Refractive Index |
1.4800 (estimate) |
|
HS CODE |
29372390 |
|
PSA |
40.46000 |
|
LogP |
3.60920 |
|
Pka |
10.27±0.60(Predicted) |
Synonyms for Estradiol 57-91-0:17a-Estradiol (8CI);1,3,5-Estratriene-3,17a-diol;13b-Methyl-1,3,5(10)-gonatriene-3,17a-diol;17-Epiestradiol;17a-Oestradiol;3,17-Dihydroxyestratriene;3,17a-Dihydroxyestra-1,3,5(10)-triene;3,17a-Dihydroxyoestra-1,3,5(10)-triene;Alfatradiol;Epiestrol;Estra-1,3,5(10)-triene-3,17a-diol;NSC 20293;Oestra-1,3,5(10)-triene-3,17a-diol;a-Estradiol;
The chemical formula of Estradiol is C18H24O2 which containing 18 Carbon atoms,24 Hydrogen atoms and 2 Oxygen atoms,and the molecular weight of Estradiol is 272.387.
Estradiol, also known as α-Estradiol or 17α-Estradiol, is a biologically active estrogen that plays a crucial role in human breast cancer cells in tissue culture. It is a white solid with the chemical structure of estra-1,3,5(10)-triene, substituted by hydroxy groups at positions 3 and 17 (the 17alpha stereoisomer). Estradiol is involved in a system with significant autocrine/paracrine functions in the developing and adult brain, which may have substantial implications for hormone replacement strategies at menopause and in the treatment of neurodegenerative disorders such as Alzheimer's disease and ischemic stroke.
InChI:InChI=1/C18H24O2/c1-18-9-8-14-13-5-3-12(19)10-11(13)2-4-15(14)16(18)6-7-17(18)20/h3,5,10,14-17,19-20H,2,4,6-9H2,1H3/t14-,15-,16+,17-,18+/m1/s1
Relevant articles related to Estradiol:
|
Article |
Source |
|
Preparation method of [3-14C] marked 17alpha-estradiol |
- Paragraph 0089; 0104-0107, (2019/06/07) |
|
Thermodynamic Meerwein-Ponndorf-Verley reduction in the diastereoselective synthesis of 17α-estradiol |
Ahmed, Gulzar,Nickisch, Klaus , p. 1 - 4 (2016/07/06) |
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